Authors: Yabo J. Honkpehedji, Anna O. Kildemoes, Koen A. Stam, Dieu L. Nguyen, Tom Veldhuizen, Angela van Diepen, Meral Esen, Peter G. Kremsner, Manfred Wuhrer, Ayôla A. Adegnika, Cornelis H. Hokke, Maria Yazdanbakhsh
Title: Parasitic infections during pregnancy in Gabon affect glycosylation patterns of maternal and child antibodies
What is this publication about?
This scientific article explores the effects of antibody changes in pregnancy on susceptibility to diseases caused by parasitic infections. Specifically, it looks at how the glycosylation of antibodies impacts immune responses in pregnancy and early childhood in low-middle-income countries. The study was conducted in Gabon, where parasitic infections are highly prevalent.
Results of the study show that glycosylation patterns of pregnant women are affected by infection status. However, this effect was diminished in their child, which shows that factors beyond maternal influence increasingly determine glycosylation patterns as infants age.
Why is this important?
The mother’s health and immune status directly influence the development, well-being, and long-term health of her child. Understanding these interactions helps improve pregnancy outcomes, reduce childhood disease risks, and inform healthcare strategies that support both maternal and infant health.
Most studies on glycosylation during pregnancy have been conducted in high-income countries. This study helps bridge that gap by focusing on a low-income, endemic region, providing valuable insights into immune adaptations in vulnerable populations.
How can this make a difference?
Understanding the interplay between maternal and child glycosylation patterns in low-middle-income countries contributes to knowledge on antibody function in health and disease. Such findings can be used in developing effective preventative and treatment strategies for vulnerable populations.